Cyanogen Bromide → HCID 178457824, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of cis-4-(5-chloro-2-nitrophenylamino)-N-isopropylcyclohexanecarboxamide (2.27 g, 6.68 mmol) in EtOH (66.8 mL) was added tin(II) chloride dihydrate (6.03 g, 26.7 mmol). The reaction was stirred at 80° C. for 90 minutes. The reaction mixture was concentrated, and the residue was partitioned between EtOAc and 1 N aqueous NaOH. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated. The cis-4-(2-amino-5-chlorophenylamino)-N-isopropylcyclohexanecarboxamide intermediate (2.07 g, 6.68 mmol) was dissolved in EtOH (20 mL), and cyanogen bromide (1.061 g, 10.02 mmol) was added. The reaction was stirred at RT for 1 hour The reaction was diluted with 200 mL DCM and washed with 1 N aqueous NaOH. The organic layer was concentrated to provide cis-4-(2-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-N-isopropylcyclohexanecarboxamide (2.77 g, 124% yield) as a brown oil. MS, m/z (C17H23ClN4O): calcd, 334.2. found, 334.8 [M+H].

Provenance & Evidence