Morpholine → HCID 178457845, compound

Participants

Reaction Steps

A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (100 mg, 0.293 mmol) and morpholine (0.256 mL, 2.93 mmol) in 2-propanol (1 mL) was irradiated in the microwave for 1 hour at 150° C. The reaction mixture was concentrated, adsorbed onto a plug of silica gel, and purified by column chromatography, eluting with 0-100% EtOAc in DCM, to provide cis-N-isopropyl-4-(2-morpholino-5-nitropyridin-4-ylamino)cyclohexanecarboxamide as a yellow powder (121 mg, quantitative yield). MS, m/z (C19H29N5O4): Calcd, 508.3. found, 509.1 [M+H].

Provenance & Evidence