Thiomorpholine 1,1-dioxide → HCID 178457846, compound

Participants

Reaction Steps

A suspension of cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (100 mg, 0.293 mmol) and thiomorpholine-1,1-dioxide (198 mg, 1.467 mmol) in 2-propanol (1 mL) was irradiated in the microwave for 90 minutes at 170° C. The reaction mixture was concentrated, adsorbed onto a plug of silica gel, and purified by column chromatography, eluting with 0-100% EtOAc in DCM, to provide cis-N-isopropyl-4-(5-nitro-2-(1,1-dioxido-4-thiomorpholinyl)pyridin-4-ylamino)cyclohexanecarboxamide as a yellow powder (112 mg, 87% yield). MS, m/z (C19H29N5O5S): Calcd, 439.2. found, 440.1 [M+H].

Provenance & Evidence