Hydrochloric Acid → HCID 66728863, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-(2-hydroxypropan-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate (0.40 g, 1.417 mmol) in DCM (10 mL) at 0° C., was added 2 M HCl in diethyl ether (3.54 mL, 7.08 mmol) dropwise. The reaction was stirred overnight at RT. After 16 hours, the white precipitate was collected by vacuum filtration, washed with ether, and dried in vacuo. The residue was resuspended in 1,4-dioxane (10 mL) and 4 M HCl in dioxane (1.78 mL, 7.08 mmol) was added. The mixture was heated to 60° C. and stirred vigorously overnight. After 16 hours, the suspension was concentrated to a white powder and dried in vacuo to generate 2-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)propan-2-ol dihydrochloride (0.373 g, 103% yield).

Provenance & Evidence