Triphenylphosphine → HCID 66728699, compound

Participants

Reaction Steps

To a solution of 3-azido-1-(pyridin-2-yl)cyclobutanecarbonitrile (3.375 g, 16.94 mmol) in THF (30 mL) and water (8 mL) was added triphenylphosphine (5.33 g, 20.33 mmol) with cooling and stirring in an ice-water bath. The mixture was stirred at RT overnight. The reaction was diluted with 1N aqueous HCl and EtOAc. The acidic aqueous layer was separated and retained. The organic layer was washed with water, and then the combined aqueous layers were washed with EtOAc and basified by addition of 6 N aq NaOH. The product amine was extracted with EtOAc. The organic phase was concentrated to afford the title compound as a colorless oil and a 3:1 mixture of geometrical isomers, which was dried under vacuum and used without further purification.

Provenance & Evidence