HCID 20701061, compound → HCID 80457303, compound

HRID 518877Notes

Reaction equation

HRID 518877 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1[O:12][CH:13]([CH3:15])[CH3:14])([O-])=O.[H][H]>CO.[Pt]=O>[CH3:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[C:5]([O:12][CH:13]([CH3:15])[CH3:14])[CH:6]=1

Participants

5

Reactant 2

HCID 20701061HCID 20701061, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 80457303HCID 80457303, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A solution of 5.0 g of 1-nitro-4-methoxy-2-(propan-2-yloxy)benzene in 300 ml of methanol is hydrogenated on 2.5 g of platinum oxide at a hydrogen pressure of 15 bar, for 2 h at ambient temperature. The mixture is filtered and the filtrate is concentrated to dryness under reduced pressure, so as to obtain 4.36 g of 4-methoxy-2-(propan-2-yloxy)aniline.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-829592b3546f48398a1dbffc7c456211
Source dataset
uspto-grants-2015_08
Patent number
US09115140B2

Reaction notes

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