反应详情

A solution of 12.3 g of acetic anhydride is added slowly to 19 ml of formic acid at ambient temperature. After one hour of stirring, a solution of 6.0 g of 4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)aniline in 28 ml of formic acid is added dropwise. The mixture is stirred at ambient temperature for 2 h and then concentrated under vacuum and taken up with water. The aqueous phase is neutralized with a saturated sodium bicarbonate solution and extracted three times with 100 ml of dichoromethane. The organic phases are dried over magnesium sulfate, filtered and concentrated under vacuum. The crude product is triturated with ethyl ether and the solid is filtered off, so as to obtain 5.0 g of N-[4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]formamide.

1. stirringThe mixture is stirred at ambient temperature for 2 h
2. concentrationconcentrated under vacuum
3. extractionextracted three times with 100 ml of dichoromethane
4. dry with materialThe organic phases are dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under vacuum
7. customThe crude product is triturated with ethyl ether
8. filtrationthe solid is filtered off