Ethyl 2-methyl-3-pyrrolecarboxylate → HCID 117831598, compound

HRID 518917Notes

Reaction equation

HRID 518917 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9][CH2:10]C)=[O:8].[CH3:12][C:13]1N[CH:15]=[CH:16][C:17]=1[C:18]([O:20]C)=[O:19].Br[C:23]1C=C(Cl)C=CC=1C=O.BrC1C(C=O)=C[C:36]2[O:41]C[CH2:39][O:38][C:37]=2C=1>>[CH3:10][O:9][C:7]([C:6]1[CH:5]=[C:4]([C:16]2[C:17]([C:18]([OH:20])=[O:19])=[CH:13][C:12]3[O:41][CH2:36][CH2:37][O:38][C:39]=3[CH:15]=2)[N:3]([CH3:23])[C:2]=1[CH3:1])=[O:8]

Participants

5

Reactant 4

HCID 136747Ethyl 2-methyl-3-pyrrolecarboxylateHCID 12333388Methyl 2-methyl-1H-pyrrole-3-carboxylateHCID 131547102-Bromo-4-chlorobenzaldehydeHCID 141428207-Bromo-2,3-dihydro-1,4-benzodioxine-6-carbaldehyde

Product 1

HCID 117831598HCID 117831598, compound

Procedure

The procedure is in accordance with the process of Preparation 4, replacing the ethyl 2-methyl-1H-pyrrole-3-carboxylate in Step A by methyl 2-methyl-1H-pyrrole-3-carboxylate and the 2-bromo-4-chlorobenzaldehyde used in Step B by 7-bromo-2,3-dihydro-1,4-benzodioxin-6-carbaldehyde.

Workup

  1. customThe procedure is in accordance with the process of Preparation 4

Sources & evidence

ORD record
ord-a2cb54e816644069a70aeabbb83de854
Source dataset
uspto-grants-2015_08
Patent number
US09115159B2

Reaction notes

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