反应详情

To a 250 mL round bottom flask equipped with a thermocouple, heating mantle, nitrogen inlet/outlet, a condenser and a stir bar was added 2-oxazolidinone (6.72 g, 77.2 mmole), 2-nonylphenol (10.0 g, 45.4 mmole), potassium hydroxide (255 mg, 4.5 mmole) and ExxonMobil™ Aromatic 100 solvent (70 mL). The resulting mixture was heated to reflux temperature for 3 h. Reaction progress was monitored by TLC and 1H NMR. The reaction mixture was then cooled, filtered over Celite® and the solvent were evaporated under reduced pressure. The crude material was purified using flash column chromatography to give the amine. 1H NMR (DMSO-d6, 400 MHz) δ 7.26-7.12 (m, 2H), 6.88-6.81 (m, 2H), 3.87 (dd. 2H, J=5.8, 5.8 Hz), 2.86 (dd, 2H, J=5.8, 5.8 Hz), 1.75-0.42 (m, 19H).

1. customTo a 250 mL round bottom flask equipped with a thermocouple
2. temperatureheating mantle, nitrogen inlet/outlet, a condenser and a stir bar
3. temperatureThe resulting mixture was heated
4. temperatureto reflux temperature for 3 h
5. customReaction progress
6. temperatureThe reaction mixture was then cooled
7. filtrationfiltered over Celite®
8. customthe solvent were evaporated under reduced pressure
9. customThe crude material was purified