Morpholine → HCID 10311146, compound

HRID 51895Notes

Reaction equation

HRID 51895 reaction equation
[CH2:1]([N:8]([CH3:30])[C:9]1[C:17]2[S:16][C:15]([NH:18][C:19](=[O:27])[C:20]3[CH:25]=[CH:24][N:23]=[C:22](Br)[CH:21]=3)=[N:14][C:13]=2[C:12]([O:28][CH3:29])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:31]1[CH2:36][CH2:35][O:34][CH2:33][CH2:32]1.C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:1]([N:8]([CH3:30])[C:9]1[C:17]2[S:16][C:15]([NH:18][C:19](=[O:27])[C:20]3[CH:25]=[CH:24][N:23]=[C:22]([N:31]4[CH2:36][CH2:35][O:34][CH2:33][CH2:32]4)[CH:21]=3)=[N:14][C:13]=2[C:12]([O:28][CH3:29])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 10796Cesium carbonateHCID 10238921N-[7-(Benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-bromo-isonicotinamide

Product 1

HCID 10311146HCID 10311146, compound

Procedure

From N-[7-(benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-bromo-isonicotinamide with morpholine and cesium carbonate. ES-MS m/e (%): 490 (M+H+, 100).

Sources & evidence

ORD record
ord-af80627262384362847302ae03be92f8
Source dataset
uspto-grants-2004_03
Patent number
US06713499B2

Reaction notes

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