Trifluoroacetic acid → HCID 86727294, compound

Participants

Reaction Steps

A solution of 3-(4(R)-methyl-3-oxo-7-phenyl-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (enantiomer 1, SFC (Table 1, Method 1), Rt=3.374 min., 0.281 g, 0.61 mmol) in TFA (4 mL) and DCM (24 mL) was stirred at ambient temperature for 3 h. The solvent was removed in vacuo to give 6-(azetidin-3-ylamino)-4(R)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (Example #1-1, Enantiomer 1, SFC (Table 1, Method 1), Rt=4.541 min., 0.192 g, 65%) as yellow solid. LC/MS (Table 1, Method 5) Rt=2.074 min.; MS m/z: 364 [M+H]+.

Provenance & Evidence