Trifluoroacetic acid → HCID 86727296, compound

Participants

Reaction Steps

A solution of 3-(4(S)-methyl-3-oxo-7-phenyl-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (enantiomer 2, SFC (Table 1, Method 1), Rt=4.333 min., 0.252 g, 0.54 mmol) in TFA (4 mL) and DCM (24 mL) was stirred at ambient temperature for 3 h. The solvent was removed in vacuo to give 6-(azetidin-3-ylamino)-4(S)-methyl-7-phenyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (Example #1-2, Enantiomer 2, SFC (Table 1, Method 1), Rt=5.572 min, 0.261 g, 100%) as yellow solid. LC/MS (Table 1, Method 5) Rt=2.117 min.; MS m/z: 364 [M+H]+

Provenance & Evidence