Acetone → HCID 22736981, compound

Participants

Reaction Steps

To a stirred solution of 0.330 g (1.4 mmol) 4-methoxy-N1-methyl-N1-(tetrahydro-pyran-4-ylmethyl)-benzene-1,3-diamine in 5 ml acetone was added dropwise 0.2 ml (1.50 mmol) benzoyl isothiocyanate and stirring continued for 16 hrs at room temperature. The mixture was then concentrated in vacuo and the residue subjected to column chromatography (1/1 hexane/ethyl acetate) to afford 0.31 g (56%) 1-benzoyl-3-{2-methoxy-5-[methyl-(tetrahydro-pyra n-4-yl)-amino]-phenyl}-thiourea as a yellow solid. ES-MS m/e (%): 422 (M+Na+, 13), 400 (M+H+, 100).

Provenance & Evidence