Trifluoroacetic acid → HCID 86727331, compound

Participants

Reaction Steps

A solution of 3-(7-isopropyl-4(R)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 1, SFC (Table 1, Method 11) Rt=2.948 min.; 0.33 g, 0.77 mmol) in DCM (8 mL) and TFA (2 mL) was stirred at ambient temperature for 2 h. The solvent was removed in vacuo to give 6-(azetidin-3-ylamino)-7-isopropyl-4(R)-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid as a pale yellow solid (Example #57-1, Enantiomer 1, SFC (Table 1, Method 11) Rt=3.79 min, 0.31 g, 92%). LC/MS (Table 1, Method 5) Rt=1.676 min.; MS m/z: 330 [M+H]+.

Provenance & Evidence