HCID 86727334, compound → HCID 86727333, compound

Participants

Reaction Steps

A solution of 3-(7-isopropyl-4(S)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 2, SFC (Table 1, Method 11) Rt=4.715 min, 0.32 g, 0.75 mmol) in DCM (8 mL) and TFA (2 mL) was stirred at ambient temperature for 2 h. The solvent was removed in vacuo to give 6-(azetidin-3-ylamino)-7-isopropyl-4(S)-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoacetic acid as a pale yellow solid (Example #57-2, Enantiomer 2, SFC (Table 1, Method 11) Rt=4.92 min, 0.31 g, 92%). LC/MS (Table 1, Method 5) Rt=1.688 min.; MS m/z: 330 [M+H]+.

Provenance & Evidence