Trifluoroacetic acid → HCID 86727338, compound

Participants

Reaction Steps

To a solution of 3-(7-cyclopropyl-4(R)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 1, SFC (Table 1, Method 12) Rt=6.01 min., 0.300 g, 0.702 mmol) in DCM (9 mL) was added TFA (1.5 mL) and the reaction mixture was stirred for 2 h at ambient temperature. The solution was concentrated in vacuo to give 6-(azetidin-3-ylamino)-7-cyclopropyl-4(R)-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (Example #64-1, Enantiomer 1, SFC (Table 1, Method 1) Rt=4.205 min., 0.291 g, 0.661 mmol, 94%). LC/MS (Table 1, Method 4) Rt=1.333 min.; MS m/z: 328 [M+H]+.

Provenance & Evidence