Trifluoroacetic acid → HCID 86727340, compound

Participants

Reaction Steps

To a solution of 3-[7-(2,4-dichloro-phenyl)-4(S)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino]-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 2, SFC (Table 1, Method 12) Rt=8.89 min., 0.280 g, 0.655 mmol) in DCM (9 mL) was added TFA (1.5 mL) and the reaction mixture was stirred for 2 h at ambient temperature. The solution was concentrated in vacuo to give 6-(azetidin-3-ylamino)-7-cyclopropyl-4(S)-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (Example #64-2, Enantiomer 2, SFC (Table 1, Method 1) Rt=5.859 min., 0.275 g, 0.624 mmol, 95%). LC/MS (Table 1, Method 4) Rt=1.331 min.; MS m/z: 328 [M+H]+.

Provenance & Evidence