HCID 86727363, compound → HCID 86727365, compound

Participants

Reaction Steps

To a solution of 4-(4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1.1 g, 2.76 mmol) in MeOH (15 mL) was added Pd/C (10%, 0.110 g) and the reaction mixture was stirred under H2 (1 atm) for 10 h. The catalyst was removed by filtration, washing with methanol (3×5 mL). The filtrate was concentrated in vacuo to give 4-(4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.05 g, 100%). LC/MS (Table 1, Method 3) Rt=1.428 min.; MS m/z: 401 [M+H]+.

Provenance & Evidence