HCID 86727369, compound → HCID 86727370, compound

Participants

Reaction Steps

To a solution of 4-(7-isopropenyl-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.035 g, 2.76 mmol) in MeOH (15 mL) was added Pd/C (10%, 0.005 g, 0.005 mmol). The reaction mixture was stirred under an H2 atmosphere (50 psi) for 10 h. The catalyst was removed by filtration and washed with methanol (3×5 mL). The filtrate was concentrated in vacuo to give 4-(7-isopropyl-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-piperidine-1-carboxylic acid tert-butyl ester (0.035 g, 100%). LC/MS (Table 1, Method 5) Rt=3.554 min.; MS m/z: 443 [M+H]+.

Provenance & Evidence