HCID 86727405, compound → HCID 86727408, compound

Participants

Reaction Steps

To a solution of tert-butyl 6-benzyl-4-(1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.147 g, 0.3 mmol) in MeOH (30 mL) was added Pd/C (10%, 0.096 g, 0.1 mmol) and the mixture was stirred under an atmosphere of H2 (50 psi) for 12 h. After filtration, the filtrate was concentrated in vacuo to give tert-butyl 2-benzyl-4-(1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate (0.147 g), which was used in the next step without further purification. LC/MS (Table 1, Method 2) Rt=2.453 min; MS m/z: 491 [M+H]+.

Provenance & Evidence