HCID 86727349, compound → HCID 90220745, compound

Participants

Reaction Steps

Racemic 3-(7-isopropyl-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yloxy)-azetidine-1-carboxylic acid tert-butyl ester (prepared from the corresponding bromide (Example #65, Step G) with similar procedure as descried in Example #57, Step A-B, 0.090 g, 0.210 mmol) was separated by chiral SFC (Table 2, Method 7) to give 3-(7-isopropyl-4(S)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yloxy)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 1, SFC (Table 1, Method 13) Rt=1.572 min.; 0.045 g, 50%) and 3-(7-isopropyl-4(R)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yloxy)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 2, SFC (Table 1, Method 13) Rt=2.104 min, 0.042 g, 47%).

Provenance & Evidence