反应详情

A solution of 3-(7-isopropyl-4(R)-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yloxy)-azetidine-1-carboxylic acid tert-butyl ester (Enantiomer 2, SFC (Table 1, Method 13) Rt=2.104 min, 0.042 g, 0.098 mmol) in DCM (2 mL) and TFA (0.5 mL) was stirred at 25° C. for 2 h. The solvent was removed in vacuo to give 6-(azetidin-3-yloxy)-7-isopropyl-4(R)-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (SFC (Table 1, Method 14), Rt=1.610 min, 0.036 g, 86%) as a pale yellow solid. LC/MS (Table 1, Method 5) Rt=2.077 min.; MS m/z: 331 [M+H]+.

1. customThe solvent was removed in vacuo