Potassium Carbonate → HCID 86727416, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.0598 g, 0.073 mmol), 6-(1-benzhydryl-3-methyl-azetidin-3-ylamino)-7-bromo-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one (Example #79, Step B, 0.20 g, 0.366 mmol), K2CO3 (0.152 g, 1.098 mmol), 2,4,6-trimethyl-1,3,5,2,4,6-trioxatriborinane (0.138 g, 1.098 mmol) in water (1 mL) and dioxane (6 mL) was stirred at 120° C. overnight. The reaction mixture was cooled to ambient temperature and the solvent was removed in vacuo. The residue was purified by preparative HPLC (Table 3, Method 13) to give 6-(1-benzhydryl-3-methyl-azetidin-3-ylamino)-4,7-dimethyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one (0.10 g, 56%). LC/MS (Table 1, Method 2) Rt=0.959 min; MS m/z: 482 [M+H]+.

Provenance & Evidence