HCID 86727452, compound → HCID 86727454, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-tert-butyl 6-benzyl-4-((R)-1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.330 g, 0.675 mmol) in MeOH (20 mL) was added Pd/C (10%, 0.033 g, 0.028 mmol) and the mixture was stirred under an atmosphere of H2 (50 psi) at 50° C. for 12 h. The reaction mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo to give crude (2S)-tert-butyl 2-benzyl-4-((R)-1-methyl-2-oxo-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate (0.320 g). LC/MS (Table 1, Method 4) Rt=2.813 min; MS m/z: 513 [M+23]+.

Provenance & Evidence