Tert-butyl 4-(1-methyl-2-oxo-8-(trifluoromethyl)-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate → 1-methyl-9-(piperidin-4-yl)-8-(trifluoromethyl)-3,5-dihydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-2(1H)-one

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Reaction Steps

A solution of tert-butyl 4-(1-methyl-2-oxo-8-(trifluoromethyl)-1,2,3,5-tetrahydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-9-yl)piperidine-1-carboxylate (0.01 g, 0.021 mmol) in DCM (5 mL) and TFA (1 mL) was stirred for 1 h at ambient temperature. The solvent was removed in vacuo to give 1-methyl-9-(piperidin-4-yl)-8-(trifluoromethyl)-3,5-dihydrobenzo[5,6][1,4]oxazino[3,4-c][1,2,4]triazin-2(1H)-one trifluoacetic acid salt as a pale yellow solid (0.01 g, 97%). LC/MS (Table 1, Method 5) Rt=3.057 min.; MS m/z: 369 [M+H]+.

Provenance & Evidence