Trifluoroacetic acid → HCID 86727492, compound

Participants

Reaction Steps

To a solution of 4-[3-fluoro-2-((R)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-7-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (enantiomer 1, 0.070 g, 0.141 mmol) in DCM (3 mL) was added TFA (1 mL) and the reaction mixture was stirred at ambient temperature for 1 h. The solvent was removed in vacuo to give (R)-7-(2-fluoro-6-piperazin-1-yl-phenyl)-4-methyl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one trifluoroacetic acid (0.06 g, 85%) as a solid. 1H NMR (CD3OD, 400 MHz): δ 7.36 (m, 1H), 7.27 (m, 2H), 7.18 (s, 1H), 6.96 (m, 2H), 4.87 (m, 1H), 4.66 (d, J=13.0 Hz, 2H), 3.08 (s, 8H), 1.51 (d, J=6.8 Hz, 3H). LC/MS (Table 1, Method 4) Rt=1.684 min; MS m/z: 396 [M+H]+. SFC (Table 1, Method 33) Rt=4.921 min.

Provenance & Evidence