Hydrochloric Acid → HCID 86727501, compound

Participants

Reaction Steps

A solution of 3-[(R)-1-((R)-7-isopropyl-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-ethyl]-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.0736 g, 0.162 mmol) in HCl (4M in EtOAc, 0.8 mL) was stirred for 1.5 h at ambient temperature. The reaction mixture was concentrated in vacuo and the residue was purified by prep-HPLC (Table 3, Method 27) to give (R)-7-isopropyl-4-methyl-6-[(R)-1-(3-methyl-azetidin-3-yl)-ethyl]-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one hydrochloric acid (0.026 g, 44%) as a solid. 1H NMR (CD3OD-d4, 400 MHz): δ 7.01 (s, 1H), 6.83 (s, 1H), 4.87-4.82 (m, 1H), 4.60 (s, 2H), 4.16 (d, J=10.8 Hz, 1H), 4.02 (d, J=10.8 Hz, 1H), 3.64 (d, J=10.8 Hz, 1H), 3.55 (d, J=10.8 Hz, 1H), 3.42-3.37 (m, 1H), 3.18-3.11 (m, 1H), 1.52 (s, 3H), 1.45 (d, J=6.8 Hz, 3H), 1.38 (d, J=6.8 Hz, 3H), 1.30 (d, J=6.8 Hz, 3H), 1.16 (d, J=6.8 Hz, 3H). LC/MS (Table 1, Method 5) Rt=2.401 min.; MS m/z: 357 [M+H]+. SFC (Table 1, Method 26) Rt=7.575 min.

Provenance & Evidence