HCID 86727512, compound → HCID 86727511, compound

Participants

Reaction Steps

To a solution of 3-methyl-3-[1-((R)-4-methyl-3-oxo-7-trifluoromethyl-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-vinyl]-azetidine-1-carboxylic acid tert-butyl ester (enantiomer 2, 0.089 g, 0.185 mmol) in MeOH (12 mL) was added 10% Pd/C (0.039 g, 0.037 mmol) and the reaction mixture was stirred under H2 at ambient temperature for 1 h. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give 3-methyl-3-[1-((R)-4-methyl-3-oxo-7-trifluoromethyl-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl)-ethyl]-azetidine-1-carboxylic acid tert-butyl ester (0.084 g, 94%). LC/MS (Table 1, Method 25) Rt=0.934 min; MS m/z: 427 [M+H−56]+.

Provenance & Evidence