Hydrochloric Acid → HCID 86727568, compound

Participants

Reaction Steps

A mixture of 3-[7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-ylamino]-3-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.008 g, 0.017 mmol) in HCl (4 M in EtOAc, 2 mL) was stirred at ambient temperature for 1 h. The solvent was removed in vacuo to give 7-(2-fluoro-phenyl)-4-methyl-6-(3-methyl-pyrrolidin-3-ylamino)-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one hydrochloride acid (0.007 g, 87%) as a white solid. 1H NMR (400 MHz, methanol-d4) δ 7.53-7.42 (m, 1H), 7.41-7.34 (m, 1H), 7.34-7.29 (m, 1H), 7.29-7.22 (m, 1H), 6.89 (s, 1H), 6.70-6.64 (m, 1H), 4.97-4.93 (m, 1H), 4.64-4.57 (s, 2H), 3.60-3.45 (m, 1H), 3.38-3.34 (m, 2H), 3.18-3.07 (m, 1H), 2.20-2.06 (m, 1H), 2.04-1.92 (m, 1H), 1.56-1.47 (m, 3H), 1.39 (m, 3H). LC/MS (Table 1, Method 5) Rt=2.272 min; MS m/z: 410 [M+H]+.

Provenance & Evidence