HCID 86727588, compound → HCID 86727589, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Pd/C (10%, 0.324 g, 3.05 mmol) in MeOH (30 mL) was added 4-[(R)-7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (1.5 g, 3.05 mmol) and the reaction mixture was stirred at 50° C. under H2 (50 psi) overnight. The reaction mixture was cooled to ambient temperature, filtered and the filtrate was concentrated in vacuo to give 4-[(R)-7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl]-piperidine-1-carboxylic acid tert-butyl ester (1.2 g, 80%) as a yellow solid. 1H NMR (400 MHz, methanol-d4) δ 7.49-7.38 (m, 1H), 7.31-7.16 (m, 3H), 7.09 (s, 1H), 6.82 (s, 1H), 5.00-4.94 (m, 1H), 4.68-4.57 (m, 2H), 4.24-4.07 (m, 2H), 2.58 (m, 3H), 1.76 (m, 2H), 1.67-1.56 (m, 2H), 1.50-1.46 (m, 12H).

Provenance & Evidence