Hydrochloric Acid → HCID 86727590, compound

Participants

Reaction Steps

To HCl (1 M in EtOAc, 10 mL) was added 4-[(R)-7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl]-piperidine-1-carboxylic acid tert-butyl ester (1 g, 2.20 mmol) and the reaction mixture was stirred at ambient temperature for 1 h. The solvent was removed in vacuo to give (R)-7-(2-fluoro-phenyl)-4-methyl-6-piperidin-4-yl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one hydrochloride (0.65 g, 81%) as a yellow solid. 1H NMR (400 MHz, methanol-d4) δ 7.51-7.41 (m, 1H), 7.32-7.27 (m, 2H), 7.23 (t, J=9.0 Hz, 1H), 7.03 (s, 1H), 6.87 (s, 1H), 5.01-4.95 (m, 1H), 4.70-4.60 (m, 2H), 3.50-3.38 (m, 2H), 3.01-2.69 (m, 3H), 2.05 (m, 2H), 1.90 (m, 2H), 1.52 (m, 3H). LCMS (Table 1, Method 5) Rt=2.351 min; MS m/z: 395[M+H]+.

Provenance & Evidence