Hydrochloric Acid → HCID 86727596, compound

Participants

Reaction Steps

A mixture of 4-[7-(2-fluoro-phenyl)-4-methyl-3-oxo-2,3,4,10-tetrahydro-9-oxa-1,2,4a-triaza-phenanthren-6-yl]-piperazine-1-carboxylic acid tert-butyl ester (0.076 g, 0.153 mmol) in HCl (4M in EtOAc, 30 mL) was stirred at rt for 2 h. The reaction mixture was concentrated in vacuo to give 7-(2-fluoro-phenyl)-4-methyl-6-piperazin-1-yl-2,10-dihydro-9-oxa-1,2,4a-triaza-phenanthren-3-one hydrochloride (0.065 g, 96%) as a white solid. 1H NMR (400 MHz, MeOD) δ 7.45-7.34 (m, 2H), 7.29-7.14 (m, 2H), 6.92 (s, 2H), 4.89 (q, J=6.8 Hz, 1H), 4.65-4.56 (d, J=13.2 Hz, 2H), 3.03 (m, 8H), 1.48 (d, J=6.8 Hz, 3H).

Provenance & Evidence