Hydrochloric Acid → HCID 86727623, compound

Participants

Reaction Steps

To a solution of HCl in EtOAc (4M, 10 mL, 40 mmol) was added (1-benzhydryl-3-methyl-azetidin-3-yl)-carbamic acid tert-butyl ester (0.750 g, 2.128 mmol) and the mixture was stirred for 2 h. The mixture was concentrated to give 1-benzhydryl-3-methyl-azetidin-3-ylamine hydrochloride salt as solid (0.600 g, 2.077 mmol, 98%). 1H NMR (CDCl3, 400 MHz): δ 9.04 (m, 3H), 7.46-7.67 (m, 4H), 7.21-7.42 (m, 6H), 4.35 (m, 2H), 3.89 (m, 2H), 1.52-1.65 (m, 3H).

Provenance & Evidence