反应详情

A 500-mL flask was purged with nitrogen and charged with 109a (1.5 g, 4.6 mmol), 10% palladium on carbon (50% wet, 200 mg), and methanol (70 mL). It was evacuated, charged with hydrogen gas, and stirred at room temperature for 10 h. The hydrogen was then evacuated and nitrogen was charged into the flask. The catalyst was removed by filtration through a pad of Celite and the filtrate was concentrated under reduced pressure to afford 109b (1.1 g, 81%) as a brown solid. MS: [M+H]+ 293

1. customA 500-mL flask was purged with nitrogen
2. customIt was evacuated
3. additioncharged with hydrogen gas
4. customThe hydrogen was then evacuated
5. additionnitrogen was charged into the flask
6. customThe catalyst was removed by filtration through a pad of Celite
7. concentrationthe filtrate was concentrated under reduced pressure