反应详情

A mixture of 109c (600 mg, 1.26 mmol) in methanol (20 mL) was added HCl/dioxane (4.0 M, 4 mL). The reaction mixture was stirred at room temperature for 4 h. It was then concentrated at reduced pressure. The residue was basified with aqueous 1.0 M NaOH and extracted with DCM. The combined organic layer was washed with H2O and concentrated under reduced pressure to afford 109d (450 mg, 95%) as yellow solid. MS: [M+H]+ 378.

1. concentrationIt was then concentrated at reduced pressure
2. extractionextracted with DCM
3. washThe combined organic layer was washed with H2O
4. concentrationconcentrated under reduced pressure