Dichloromethane → HCID 59147628, compound

Participants

Reaction Steps

Naphthalen-1-ylboronic acid (5.30 g, 30.8 mmol), 6-hydroxynaphthalen-2-yl trifluoromethanesulfonate (7.5 g, 25.7 mmol), potassium phosphate (10.90 g, 51.3 mmol) were mixed in 200 mL of THF and 20 mL of water and bubbled with nitrogen for 20 minutes. Pd2(dba)3 (0.235 g, 0.257 mmol) and [1,1′-biphenyl]-2-yldicyclohexylphosphine (0.180 g, 0.513 mmol) were added to the reaction mixture. The reaction was refluxed overnight. After cooling, the reaction mixture was extracted with ethyl acetate and washed with brine. The organic layer was separated and dried over MgSO4. The residue was purified by column using 1:2 hexanes:DCM (v/v) to give [1,2′-binaphthalen]-6′-ol (8.4 g, 95% yield).

Provenance & Evidence