Potassium Hydroxide → HCID 67609079, compound

HRID 519422Notes

Reaction equation

HRID 519422 reaction equation
[OH-].[K+].Cl.[C:4]([NH2:12])(=[NH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH:20]=[CH:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O>C(O)C>[Br:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20]1[CH:21]=[C:22]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:12]=[C:4]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:11]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 80289Benzamidine, hydrochlorideHCID 395513AC1L9AJF

Product 1

HCID 67609079HCID 67609079, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

23 g (409 mmol) of potassium hydroxide are dissolved in 500 ml of ethanol, 40 g (255 mmol) of benzamidine hydrochloride 2 and 129 g (452 mmol) of (3-(bromophenyl)-1-phenyl-2-propen-1-one 1, dissolved in 500 ml of ethanol, are added at room temperature, and the mixture is stirred under reflux for 3 h. After cooling to room temperature, the precipitated solid is filtered off with suction, washed with a little ethanol and dried, leaving 55 g (129 mmol), 50%, of the product in the form of colourless crystals.

Workup

  1. additionare added at room temperature
  2. temperatureunder reflux for 3 h
  3. filtrationthe precipitated solid is filtered off with suction
  4. washwashed with a little ethanol
  5. customdried
  6. customleaving 55 g (129 mmol), 50%

Sources & evidence

ORD record
ord-9269286c20384b8a8ba764f93586db4e
Source dataset
uspto-grants-2015_08
Patent number
US09118022B2

Reaction notes

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