참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-2-(trifluoromethyl)benzaldehyde | HCID 12187218 | — |
| 반응물 | 2-Cyano-phenylboric acid | HCID 21708089 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4'-Formyl-3'-(trifluoromethyl)biphenyl-2-carbonitrile | HCID 86644026 | 32.7% |
반응 단계
A mixture of 4-bromo-2-(trifluoromethyl)benzaldehyde (9 g), 2-cyano-phenylboric acid (9.5 g), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (2.9 g), tetrabutylammonium bromide (1.15 g), 2M aqueous sodium carbonate solution (30 mL) and toluene (100 mL) was stirred at 100° C. overnight under an argon atmosphere. The reaction mixture was diluted with ethyl acetate, washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography to give the title compound as a colorless solid (3.2 g, 32%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09115136B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-c9feda5c388842dfb335337ba5cd470b |
|---|
| 출처 메모 | uspto-grants-2015_08 |
|---|
