HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 519871Generated: October 29, 2026
1-benzyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine → N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine
https://huagongshe.com/reaction/519871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-benzyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine | HCID 28767951 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine | HCID 67009691 | 87.2% |
Reaction Steps
A mixture of 1-benzyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-amine (3.00 g), palladium-carbon (10 wt %, 2.33 g) and ethanol (100 mL) was stirred under a hydrogen atmosphere at 50° C. and 5 atm for 9 hr. The insoluble material was filtered off, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound as a colorless solid (1.70 g, 87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115136B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-6955a8c739264a32bbc84b33dbbf54a3 |
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| Source note | uspto-grants-2015_08 |
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