HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 519901Generated: October 26, 2026
Azobisisobutyronitrile → 4'-(Bromomethyl)-3'-fluorobiphenyl-2-carbonitrile
https://huagongshe.com/reaction/519901
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | (Trifluoromethyl)benzene | HCID 7368 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-(3-Fluoro-4-methylphenyl)benzonitrile | HCID 54238624 | — |
| Product | 4'-(Bromomethyl)-3'-fluorobiphenyl-2-carbonitrile | HCID 57460074 | — |
Reaction Steps
To a mixture of 3′-fluoro-4′-methylbiphenyl-2-carbonitrile (110 g), N-bromosuccinimide (97.3 g) and benzotrifluoride (1.0 L) was added azobisisobutyronitrile (1.71 g), and the mixture was heated to an internal temperature of 78° C. and stirred for 16 hr. The reaction mixture was cooled to around 40° C., and the insoluble material was removed to give a solution of 4′-(bromomethyl)-3′-fluorobiphenyl-2-carbonitrile in benzotrifluoride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09115136B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-514207afccb74fdfbc3112d1a64b872c |
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| Source note | uspto-grants-2015_08 |
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