反应详情

0.8 g of methyl 6-[(4,6-dimethoxypyrimidin-2-yl)oxy]quinolin-5-carboxylate was dissolved in 10 ml of methanol and 20 ml of methoxyethane, and 5 ml of an aqueous solution containing 0.39 g of potassium hydroxide was added thereto at 40° C. The mixture was extracted with dichloromethane. The aqueous layer was acidified (pH=4) with a 10% hydrochloric acid aqueous solution, and formed precipitates were collected by filtration and dried to obtain 0.5 g (yield: 66.0%) of the desired compound. mp: 195°-198° C.

1. additionwas added
2. customat 40° C
3. extractionThe mixture was extracted with dichloromethane
4. customformed
5. customprecipitates
6. filtrationwere collected by filtration
7. customdried