HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol → 1-(2-Hydroxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol | HCID 14853203 | — |
| Reactant | 3-(4-Isothiocyanatophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole | HCID 118590165 | — |
| Product | 1-(2-Hydroxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea | HCID 118590130 | — |
Reaction Steps
The title compound was prepared with 2-amino-2-(4-(trifluoromethyl)phenyl)ethanol and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as an off-white solid (0.250 g, 53%): ESIMS m/z 568 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326516B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3155e27bfa344f75b83b95e6e74eb016 |
| Source note | uspto-grants-2016_05 |