Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-2-(4-fluorophenyl)ethanol → 1-(1-(4-Fluorophenyl)-2-hydroxyethyl)-3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-2-(4-fluorophenyl)ethanol | HCID 14853201 | — |
| 반응물 | 3-(4-isothiocyanatophenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole | HCID 118590171 | — |
| 생성물 | 1-(1-(4-Fluorophenyl)-2-hydroxyethyl)-3-(4-(1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea | HCID 118590180 | — |
반응 단계
The title compound was prepared with 2-amino-2-(4-fluorophenyl)ethanol and 3-(4-isothiocyanatophenyl)-1-(4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole and isolated as a white solid (1.4 g, 99%): 1H NMR (300 MHz, CDCl3) δ 8.07 (s, 1H), 7.67 (d, J=8.1 Hz, 2H), 7.31 (d, J=8.4 Hz, 2H), 7.21 (d, J=8.6 Hz, 2H), 6.82-6.67 (m, 4H), 6.44 (q, J=7.7, 7.1 Hz, 4H), 6.33 (d, J=8.3 Hz, 1H), 5.09 (s, 1H), 3.44 (dd, J=10.9, 4.2 Hz, 1H), 3.32 (dd, J=11.2, 4.7 Hz, 1H); ESIMS m/z 502 ([M+H]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09326516B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-14078273a9b34a31a0ad9d5b8495ec31 |
| 출처 메모 | uspto-grants-2016_05 |