3-Amino-3-[4-(trifluoromethyl)phenyl]propan-1-ol → HCID 118590164, compound

HRID 520245Notes

Reaction equation

HRID 520245 reaction equation
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][CH:7]=1)[CH2:3][CH2:4][OH:5].[N:16]([C:19]1[CH:24]=[CH:23][C:22]([C:25]2[N:29]=[CH:28][N:27]([C:30]3[CH:35]=[CH:34][C:33]([O:36][C:37]([F:40])([F:39])[F:38])=[CH:32][CH:31]=3)[N:26]=2)=[CH:21][CH:20]=1)=[C:17]=S>>[F:40][C:37]([F:38])([F:39])[O:36][C:33]1[CH:32]=[CH:31][C:30]([N:27]2[CH:28]=[N:29][C:25]([C:22]3[CH:23]=[CH:24][C:19]([NH:16][C:17]4[O:5][CH2:4][CH2:3][CH:2]([C:6]5[CH:11]=[CH:10][C:9]([C:12]([F:13])([F:14])[F:15])=[CH:8][CH:7]=5)[N:1]=4)=[CH:20][CH:21]=3)=[N:26]2)=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 448912413-Amino-3-[4-(trifluoromethyl)phenyl]propan-1-olHCID 1185901653-(4-Isothiocyanatophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

Product 1

HCID 118590164HCID 118590164, compound

Procedure

The title compound was prepared with 3-amino-3-(4-(trifluoromethyl)phenyl)propan-1-ol and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as an off-white solid (0.10 g, 43%).

Sources & evidence

ORD record
ord-f882a67ce4634ecabdcaa4beb6086fed
Source dataset
uspto-grants-2016_05
Patent number
US09326516B2

Reaction notes

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