1-(2-Chlorophenyl)piperazine → 3-(2-(4-(2-chlorophenyl)piperazine-1-yl)ethyl)-2-ethylquinazoline-4 (3H)-one

HRID 520291Notes

Reaction equation

HRID 520291 reaction equation
[CH2:1]([C:3]1[N:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23](C(F)(F)F)[CH:22]=3)[CH2:17][CH2:16]2)[C:11](=[O:31])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[CH3:2].[Cl:32]C1C=CC=CC=1N1CCNCC1>>[Cl:32][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[N:18]1[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][N:12]2[C:11](=[O:31])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=[C:3]2[CH2:1][CH3:2])[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 4156281-(2-Chlorophenyl)piperazineHCID 668251862-ethyl-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazine-1-yl)ethyl)quinazoline-4(3H)-one

Product 1

HCID 569442093-(2-(4-(2-chlorophenyl)piperazine-1-yl)ethyl)-2-ethylquinazoline-4 (3H)-one

Procedure

This compound was prepared in compliance with the procedure described in 7d, using 1-(2-chlorophenyl)piperazine instead of 1-(3-(trifluoromethyl)phenyl)piperazine.

Workup

  1. customThis compound was prepared in compliance with the procedure

Sources & evidence

ORD record
ord-43c8e985ea2b4c038cf1f46e382fbb18
Source dataset
uspto-grants-2016_05
Patent number
US09326984B2

Reaction notes

Loading…