関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Di-tert-butyl 4,4-dimethylpyrrolidine-1,2-dicarboxylate | HCID 21016684 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 4,4-Dimethylpyrrolidine-2-carboxylic acid | HCID 286642 | — |
反応手順
A mixture of 137e (27 g, 90 mmol) and TFA (100 mL) in DCM (200 mL) was stirred at 20° C. for 16 h. See FIG. 1. The reaction solution was concentrated under reduced pressure to give 4,4-dimethylpyrrolidine-2-carboxylic acid 137f as a brown oil (27 g, TFA salt). 1H NMR (400 MHz, CDCl3): δ 12.08 (br s, 2H), 9.56 (br s, 1H), 7.77 (br s, 1H), 4.52 (s, 1H), 3.20 (s, 2H), 2.30-2.24 (m, 1H), 2.00-1.94 (m, 1H), 1.17 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09326985B2 |
|---|
| 出典データセット | uspto-grants-2016_05 |
|---|
| ORD ID | ord-d713967d181849d794cddc55aa6bb726 |
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| 出典メモ | uspto-grants-2016_05 |
|---|
