Dimethylformamide → 1,3-dihydro-1,3-dioxo-2H-isoindole-2-propionyl chloride

Beteiligte Stoffe

Reaktionsschritte

To a solution of 137g (20.0 g, 91 mmol) in DCM (250 mL) were added oxalyl chloride (13.8 g, 109 mmol) and DMF (0.1 mL). See FIG. 2. The mixture was stirred at RT for 4 h. Upon reaction completion, the mixture was concentrated to give 3-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 137h (20.0 g, 92%) as a white solid.

Herkunft & Nachweise