化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 4-Bromo-2-fluorobenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | 100.1% |
反応手順
To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09326985B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-54e8f043908945eba44edd67a3401a95 |
| 出典メモ | uspto-grants-2016_05 |