Hydrochloric Acid → HCID 117780376, compound

Participants

Reaction Steps

To a mixture of 144i (2.0 g, 6.0 mmol) in EtOAC (10 mL) was added HCl in EtOAC (20 mL, 4 M) at RT. See FIG. 3. The reaction mixture was stirred at room temperature for 1 h and then concentrated under reduced pressure. The crude residue was triturated with MTBE (20 mL) to give 2.0 g (85.9%) of 6-(difluoromethoxy)-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one 144j. 1H NMR (400 MHz, CDCl3) δ 6.80-6.85 (m, 2H), 6.40-6.76 (m, 1H), 6.19 (s, 1H), 3.51-3.55 (m, 2H), 2.98-3.01 (m, 2H); MS-ESI [M+H]+=232.0.

Provenance & Evidence