Ethyl 3-(3-(trifluoromethoxy)phenyl)acrylate → Ethyl 3-[3-(trifluoromethoxy)phenyl]propanoate
Reaction equation
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][CH:9]=1>CO.[Pd]>[F:1][C:2]([F:17])([F:18])[O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:8][CH:9]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 15 °C
Procedure
To a solution of 158c (12.0 g, 46.1 mmol) in methanol (100 mL) was added 10% Pd/C (1.0 g), and the reaction mixture was stirred at 15° C. for 16 h under hydrogen atmosphere. See FIG. 4. The resulting mixture was filtered, and the filtrate was concentrated under reduced pressure to afford ethyl 3-(3-(trifluoromethoxy)phenyl)propanoate 158d (11.0 g, crude) as a colorless solid.
Workup
- filtrationThe resulting mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-e6739f086c7c4d368d3ef9bf2118932c
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09326985B2
Reaction notes
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